This study was to find out the computer studies instruction challenges among senior secondary schools in Uyo. The study adopted the descriptive survey design of correlation type. The study area was Ikot Ekpene Local Government Area. The main instrument of the study was a questionnaire. Face and content validation of the instrument was carried out to ensure that the instrument has the accuracy, appropriateness, completeness and the language of the study under consideration. The researcher subjected the data generated for this study to appropriate statistical techniques. The study concluded that there are some basic strategies that could be adopted in order to improve the teaching of computer studies in secondary schools. The study is of the view that computer studies should provide sound basis for further training in computer studies at the tertiary level of education thus should be relied upon to enable students acquire the basic skills and knowledge needed to either secure a job and earn a living or to pursue further studies in the area computer and information science. The study recommended that the school administrators should as a matter of urgency liase with private sectors to provide computers and other instructional materials needed for teaching of computer studies. Parents through the PTA and other major stakeholders of our education should assists our secondary schools by donating instructional facilities like laptops, desktop computers, multimedia, generating sets, internet etc to enable students practice and acquire the skills of computing.